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欧盟评估一种纤维素酶的安全性

放大字体  缩小字体 时间:2022-07-04 11:28 来源:食品伙伴网 作者: 泽夕   
核心提示:2022年7月1日,欧盟食品安全局就一种纤维素酶(cellulase)的安全性评价发布意见。
   食品伙伴网讯  2022年7月1日,欧盟食品安全局就一种纤维素酶(cellulase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因里氏木霉菌株AR-852生产的,旨在用于烘焙过程、酿造过程、蒸馏酒精生产、葡萄酒和葡萄酒醋生产以及用于果汁生产的水果和蔬菜加工。
 
  经过评估,专家小组认为,在预期的使用条件下(蒸馏酒精生产除外),不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。根据所提供的数据,评估小组得出结论,这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下:
 
  The food enzyme cellulase (4-(1,3;1,4)-β-d-glucan 4-glucanohydrolase; EC 3.2.1.4) is produced with the genetically modified Trichoderma reesei strain AR-852 by AB Enzymes GmbH. The genetic modifications did not give rise to safety concerns. The food enzyme is considered free from viable cells of the production organism and its DNA. The food enzyme is intended to be used in five food manufacturing processes: baking processes, brewing processes, distilled alcohol production, wine and wine vinegar production, and fruit and vegetable processing for juice production. As residual amounts of total organic solids (TOS) are removed by distillation, dietary exposure was only calculated for the other four food processes. Dietary exposure to the food enzyme TOS was estimated to be up to 0.1 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1,000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 10,000. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use (other than distilled alcohol production) the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
 
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日期:2022-07-04
 
 
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